Abstract
To examine how myocardial perfusion is controlled by a feedforward (termed “central command”) and feedback (exercise pressor reflex) neural mechanisms during exercise, left ventricular (LV) myocardial perfusion was measured during either electrical stimulation of subthalamic locomotor region (SLR), the electrical or chemical stimulation of which is known to elicit coordinated locomotion and concomitant cardiorespiratory responses, or electrical stimulation of tibial nerve in either anesthetized or decerebrated rats. Changes in LV myocardial perfusion and muscle blood flow to the right gastrocnemius muscle were measured by a Laser‐Doppler flowmetry. Arterial pressure and heart rate (HR) were also measured. Stimulation of SLR rapidly increased both LV myocardial perfusion and mean arterial pressure (MAP) in a stimulus intensity‐dependent manner. Stimulation of SLR also increased gastrocnemius muscle blood flow gradually throughout the stimulus period. Beta‐adrenergic blockade attenuated the rapid increase in myocardial perfusion evoked by SLR stimulation. Tibial nerve stimulation also rapidly increased LV myocardial perfusion and MAP. These results suggest that both feedforward and feedback control of the myocardial perfusion play an important role in meeting myocardial demands for adequate blood supply.
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