Abstract
IntroductionPeople of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid...
Highlights
People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood
Higher levels of most circulating amino acids andceramides were associated with higher risk for T2D, while higher levels of glycine, glutamine, lactosylceramides and most acylcarnitines were associated with lower T2D risk
This suggests that the mechanisms underlying ethnic differences in amino acid and lactosylceramide concentrations could be investigated further to identify whether the mechanisms contribute to or predict the higher T2D risk among South-Asian Surinamese compared with Dutch
Summary
People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined the associations with T2D. Amino acid and lactosylceramide concentrations were higher among South-A sian Surinamese than Dutch (eg, isoleucine 65.7 (SD 16.3) vs 60.7 (SD 15.6) μmol/L). Conclusions Overall, these data suggest that the disturbances underlying amino acid and sphingolipid metabolism may be predictive of T2D risk in populations of both South Asian and European background. These observations may be used as starting point to unravel the underlying metabolic disturbances.
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