Contribution to the study of morphological changes in filamentous fungi and yeasts induced by antibiotics

Abstract

Summary Improved methods for detection of morphological changes induced in fungi by antibiotics are described. The methods standardize the cultivation conditions and sampling, and thus allow to detect even minimal morphological differences. In filamentous fungi the method described allows, moreover, the estimation of quantitative morphological changes and in yeasts it suppresses the distortion of results by the natural morphological variability and enables to use the experimental material for electronmicroscopic observation. Both methods were applied in the study of morphological changes caused by the new antibiotic mucidin.