Abstract
The pH of normal cattle lenses and of human cataractous lenses was determined. The acidity of the latter was found to be favorable to autolysis of lens protein. That this had occurred was proved by the presence of free tyrosin and tryptophan, substances not present in normal cattle lenses. Lipoids do not affect the rate of autolysis, but change the isoelectric point of the lens protein. The pronounced yellow or brown color of cataractous lenses is not due to enzymatic melanin formation, but more probably to the oxidation of free tryptophan. This research was conducted in the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University. The pH of normal cattle lenses and of human cataractous lenses was determined. The acidity of the latter was found to be favorable to autolysis of lens protein. That this had occurred was proved by the presence of free tyrosin and tryptophan, substances not present in normal cattle lenses. Lipoids do not affect the rate of autolysis, but change the isoelectric point of the lens protein. The pronounced yellow or brown color of cataractous lenses is not due to enzymatic melanin formation, but more probably to the oxidation of free tryptophan. This research was conducted in the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University.
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