Contribution to the Management of Abnormal Insulin Secretion in Diabetes of Pregnancy using Antidiabetic Medicinal Plants in Cameroon

Abstract

Abnormal insulin secretion occurs during hypoinsulinism and hyperinsulinism. Hypoinsulinism is absolute or relative insulin insufficiency which produces a very common clinical sickness called diabetes mellitus. Hyperinsulinism designs an overhead normal level of insulin in a patient’s blood. Hyperinsulinism is the disproportionate production of insulin by tumors of the pancreatic β cells. Patients who suffer from hyperinsulinism disorder undergo hypoglycemic crises, weakness, intense perspiring, and vertigo. This alteration is not known by people of surrounding areas of developing countries like Cameroon. To identify previous work used to write this article a systematical search was done using engines including: “Antidiabetic plants help to control the hyperinsulism in pregnant diabetic women or animals” and “Toxicity of a given recorded plant name” used to verify the harmlessness of recorded plants. Plants that caught our attention are plants already used by hinterlands diabetic women in Cameroon. An increase in insulin secretion by fetal pancreas and placenta coincides with an increased number of insulin-producing B-cells to lower glucose levels in the bloodstream and promote the storage of glucose in adipose and muscle tissue, liver and other body tissues. It was demonstrated that insulin released from the liver stimulate also glucose uptake and naturally maternal insulin does not cross the placenta. Well controlled healthy pregnant women have a good chance of having a normal pregnancy and birth. But in developing countries diabetes is not generally well controlled during pregnancy in many hinterland areas and still affecting maternal and baby health. At the time of birth newborns diabetic mothers are still often larger, and after birth their vagina is harder and may upsurge the risk for nerve injuries and other trauma during birth. Also many risk including birth defect of the lower spine, birth defect of the brain, and limb result from pre-existing diabetes. Screening of all pregnancy for insulin resistance and early intervention may help to reduce these connected complications. Do antidiabetic plants more economical and available, taken by indigenous gestational diabetics control GDM?