Abstract
The rate of disappearance of radiolabelled ergot peptide alkaloids from the lumen of the gastrointestinal tract of rats, in situ, was studied. The intestinal absorption of these compounds is slow and incomplete. Disappearance rate is increased considerably by addition of mucolytic enzymes and by high local drug concentrations. A two compartment model of absorption kinetics of the ergot peptide alkaloids, depending on two parameters, is described. Based on these findings it is suggested that the mucus layer is the rate-limiting barrier for the intestinal absorption of ergot peptide alkaloids due to interactions via hydrogen bonds.
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