Abstract
Many members of The Japanese Environmental Mutagen Society (JEMS) have significantly contributed to guidelines on chemical genotoxicity. The guidelines have been useful for the hazard identification and risk assessment of genotoxic chemicals. However, risk assessors and developers of drugs and other commercial products might eliminate beneficial chemicals from further development simply based on positive results of genotoxicity testing. Experts in the field of genotoxicity should better characterize the biological significance of genotoxicants and more correctly assess human risk. I hope that one of the next challenges undertaken by JEMS will be to assess the human risk of genotoxic chemicals more correctly based on the precise analysis of their mechanisms of action.
Highlights
Many members of The Japanese Environmental Mutagen Society (JEMS) have significantly contributed to guidelines on chemical genotoxicity
Risk assessors and developers of drugs and other commercial products might eliminate chemicals from further development based on positive results of genotoxicity testing
How can experts better characterize the biological significance of genotoxicants and more correctly assess human risk? A general approach for examining chemicals is to use a battery of genotoxicity tests that can detect different kinds of genotoxicity, i.e., use a weight of evidence (WoE) approach
Summary
Many members of The Japanese Environmental Mutagen Society (JEMS) have significantly contributed to guidelines on chemical genotoxicity. Strategic guidelines (or international consensus papers) have been published to describe how chemical genotoxicity should be evaluated and regulated to reduce the risk for humans. These guidelines have been very useful for the hazard identification and risk assessment of genotoxic chemicals.
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