Abstract
BackgroundA human syndecan-4 genetic variant (rs1981429) has previously been associated with lean tissue mass and intra-abdominal fat, and SNP rs4599 with resting energy expenditure in healthy early pubertal children. These variations could thus cause overweight and hypothetically lead to hypertension. Their association with body mass index and blood pressure was therefore studied in a Finnish cohort of adults.MethodsThe data was collected from the Tampere adult population cardiovascular risk study (TAMRISK). A total of 279 cases with hypertension and/or coronary artery disease (CAD), and 488 non-hypertensive healthy controls were selected from a Finnish periodic health examination 50-year-old cohort. Information was available also from their 45-year examination. DNA was extracted from buccal swabs and human syndecan-4 gene SNPs were analyzed using KASP genotyping.ResultsThe SNP rs1981429 variant TT was significantly associated with hypertension, as compared to variants TG and GG at the age of 50 years (p=0.015). The variant TT was also associated with increased BMI at the ages of 45 and 50 years (p=0.008 and p=0.026, respectively). In addition, TT genotype associated with increased CAD prevalence (P=0.013). No significant associations between rs4599 variants and hypertension or BMI were found. In haplotype analysis the number of alleles T (rs1981429)/C (rs4599) was linearly associated with CAD prevalence; the highest prevalence (13%) was in haplotype TT/CC and lowest prevalence (1%) in haplotype GG/TT (p=0.01).ConclusionSyndecan-4 polymorphisms were associated with essential hypertension, BMI, and CAD prevalence in the TAMRISK study.
Highlights
A human syndecan-4 genetic variant has previously been associated with lean tissue mass and intra-abdominal fat, and SNP rs4599 with resting energy expenditure in healthy early pubertal children
Syndecans are cell surface proteoglycans with heparan sulfate chains that bind to other ECM components, growth factors, clotting factors, and even to enzymes involved in lipid metabolism [2]
Subjects The data for the Tampere adult population cardiovascular risk study (TAMRISK) study was collected from periodic health examinations (PHE) done for 50-year-old men and women living in Tampere, Finland [12]
Summary
A human syndecan-4 genetic variant (rs1981429) has previously been associated with lean tissue mass and intra-abdominal fat, and SNP rs4599 with resting energy expenditure in healthy early pubertal children. These variations could cause overweight and hypothetically lead to hypertension. Syndecan-4 is upregulated in the hypertrophic left ventricle following myocardial infarction, suggesting a role for this proteoglycan family in cardiac remodeling [5]. Experimental data has suggested that syndecan-4 plays an important role in the immune response of the heart to increased pressure, influencing cardiac remodeling [6]
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