Abstract
Contribution of sensory nerves within osteochondral channels to pain in human and rat knee osteoarthritis
Highlights
Knee osteoarthritis (OA) is a common cause of pain and disability and pain is the most common reason sufferers seek medical help
We previously shown that subchondral pathology, including increased nerve growth factor (NGF) expression in osteochondral channels, was associated with symptomatic knee OA
Sensory nerve densities have been associated with pain in other diseases, but it is unclear whether sensory nerve growth at the osteochondral junction contributes to OA pain
Summary
Knee osteoarthritis (OA) is a common cause of pain and disability and pain is the most common reason sufferers seek medical help. Abstracts / Osteoarthritis and Cartilage 27 (2019) S23eS91 completed the PainDetect questionnaire in which a score of 13 is interpreted as reflecting neuropathic-like pain. For those with unilateral ROA or unilateral FKP, the prevalence of abnormalities were similar in the ipsilateral and contralateral knee.
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