Abstract
Comorbidity scores to predict mortality are very useful to facilitate decision-making for personalized patient management. This study aim was to assess the contribution of medico-administrative data in addition to French Renal Epidemiology and Information Network (REIN) data to the development of a risk score to predict the 1-year all-cause mortality in patients with End Stage Renal Disease (ESRD), and to compare it with previous scores. Data from a derivation sample (n = 6336 patients who started dialysis in 2015 in France) obtained by linking the REIN and the French National Health Insurance Information System databases were analyzed with multivariate Cox models to select risk factors to establish the score. A randomly chosen validation sample (n = 2716 patients who started dialysis in 2015) was used to validate the score and to compare it with the comorbidity indexes developed by Wright and Charlson. The ability to predict one-year mortality of the score constructed using REIN data linked to the medico-administrative database was not higher than that of the score constructed using only REIN data (i.e., Rennes score). The Rennes score included five comorbidities, albumin, and age. This score (AUC = 0.794, 95%CI: 0.768–0.821) outperformed both the Wright (AUC = 0.631, 95%CI: 0.621–0.639; p < 0.001) and Charlson (AUC = 0.703, 95%CI: 0.689–0.716; p < 0.001) indexes. Data from the REIN registry alone, collected at dialysis start, are sufficient to develop a risk score that can predict the one-year mortality in patients with ESRD. This simple score might help identifying high risk patients and proposing the most adapted care.
Highlights
The number of patients with End Stage Renal Disease (ESRD) continues to increase in France and worldwide, due to aging and the increased prevalence of type 2 diabetes[1]
Afterwards, only few authors developed new comorbidity scores adapted to specific ESRD populations, such as patients on hemodialysis[9], elderly patients with ESRD11–13, and patients with ESRD covered by Medicare[10,14]
We described the development and validation of a simple comorbidity score that summarizes in one index several risk factors to predict the one-year mortality in patients with ESRD
Summary
The number of patients with End Stage Renal Disease (ESRD) continues to increase in France and worldwide, due to aging and the increased prevalence of type 2 diabetes[1]. The Charlson comorbidity index[3] is the most widely used score, in the clinic and in studies, to assess survival of patients with ESRD4–7. It was developed in patient populations with various diseases, and it is not disease-specific. No study focused on the development of a new comorbidity score to predict the 1-year mortality of all French patients at dialysis start.
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