Contribution of magnesium in binding of factor IXa to the phospholipid surface: implications for vitamin K-dependent coagulation proteins.

Abstract

rs4962153 showed an association with cryptogenic stroke(Table 1). This association is interesting in view of the fact thatprothrombotic variants have been suggested as risk factors forcryptogenicstroke[8],buttherearenostudiesonADAMTS13in this subtype. We found no significant associations for any ofthe other IS subtypes. However, whether this is due to asubtype-specific effect of ADAMTS13 gene variation or a lackof statistical power in the smaller subgroups cannot bedetermined from these findings.In conclusion, three SNPs in the ADAMTS13 gene werefound to be associated with IS in the present population ofrelatively young patients from western Sweden. The SNPrs4962153 showed significant associations with both overallischemicstrokeandthesubtypecryptogenicstroke.Tothebestof our knowledge, this is the first study investigating ADAM-TS13 gene variants in a large cohort of patients with IS and indifferent subtypes of IS. Thus, further studies are needed inorder to investigate whether the present finding can bereplicated, and whether there are associations for othersubtypes apart from cryptogenic stroke.AcknowledgementsThis study was supported by the Swedish Research Council(K2008-65X-14605-06-3), the Swedish state (ALFGBG-11206), the Swedish Heart Lung Foundation (20070404), andtheRuneandUllaAmlo¨v,theJohnandBritWennerstro¨m,thePer-Olof Ahl, the Yngve Land, the Ma¨rta Lundqvist, and theMagnus Bergvall foundations.Disclosure of Conflict of InterestsThe authors state that they have no conflict of interest.References