Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology.

Salvador Herrera-Pérez,José Antonio Lamas,Lola Rueda-Ruzafa,Ana Campos-Ríos

doi:10.3390/ijms22126635

Salvador Herrera-Pérez, José Antonio Lamas + Show 2 more

Open Access

https://doi.org/10.3390/ijms22126635

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Abstract

Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome.

Highlights

TWIK-Related Acid-Sensitive K+ Channels (TASK), TWIK and TWIK-Related K+ Channels (TREK) channels are expressed in the mammalian heart (Figure 1), 2although the expression of other K2P subfamilies in the heart seems to depend on the species analyzed
Several K2P channels have been localized in cardiac tissue, the presence of TASK-1, TWIK-1 and TREK-1 seems to be prominent [28,39,40,67,68,86]
Channels are expressed heterogeneously in the heart and in a species-dependent manner, and whereas TWIK-1 channels are more strongly expressed in the atrium than in the ventricles in humans, in murids this channel is expressed strongly throughout the heart [39,40,41]

Summary

Introduction

TASK, TWIK and TREK channels are expressed in the mammalian heart (Figure 1), 2although the expression of other K2P subfamilies in the heart seems to depend on the species analyzed. TASK and TREK channels, focusing on their putative roles in cardiac physiology and their involvement in coronary pathologies. TWIK channels are human sensitive to channel changes cloned in pHi,[1], barium considered to be part of the “tandem of pore domains in a weak inward rectifying quinine [35,36,37]. More strongly in human ventricular than atrial myocytes on RT-PCR and and TWIK channels are sensitive to changes in pHi, barium quiNorthern blot analysis [1,38].

Northern blot analysis

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Discussion and Conclusions