Abstract
The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure.
Highlights
Neurocognitive disorders, which were earlier identified as dementia, denote a range of disorders that affect the brain and cause worsening in one or more cognitive areas
The results provide the potential role of ID3 in regulating development of micro-vascular lesions and vascular endothelial cell survival prompted by environmental chemicals such as polychlorinated biphenyl 153 (PCB153) [34,35]
On the evidence discussed in this review, we and haveexposure demonstrated that such exposure to endocrine disruptors (EEDs) may Inhibitor of differentiation (ID) proteins to alter molecular changing as polychlorinated biphenyls (PCBs) and bisphenol A (BPA)
Summary
Neurocognitive disorders, which were earlier identified as dementia, denote a range of disorders that affect the brain and cause worsening in one or more cognitive areas. An estimated 13–16 million individuals 18 years old and older are afflicted with these types of disorders This type of disorder frequently affects older people, it is not part of the standard aging development and has the capability to affect young people as well. Neurocognitive disorders may be susceptible to estrogenic endocrine disruptors or EEDs. Endocrine disruptors modify hormone function or production, including anthropogenic chemicals, heavy metals, and phytoestrogens. This review is concentrated on connecting EEDs to ID interactions leading to altered outcomes in neurocognitive disorders. More study in these capacities may uncover innovative or applicable beneficial modalities and deliver approaches for neurocognitive outcomes with
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