CONTRIBUTION OF HUMAN α-DEFENSIN 1, 2, AND 3 TO THE ANTI-HIV-1 ACTIVITY OF CD8 ANTIVIRAL FACTOR

Abstract

Zhang L, Yu W, He T, et al. Science. 2002;298:995–1000 Since 1986, it has been known that CD8+ T-cells from human immunodeficiency virus (HIV)-infected, immunologic stable long-term survivors secrete a soluble factor that has been termed CD8 antiviral factor (CAF). The molecular identity of CAF has remained elusive. Some of the antiviral activity in CAF appears to be mediated by β−chemokines, MIP-1α, MIP-1 β and RANTES; however, these factors do not account …