Abstract
The aim of this study was to investigate whether certain DR alleles might contribute to the genetic susceptibility among adult polycystic kidney disease patients in Egypt. This case–control study involved human leukocyte antigen (HLA)-DR typing for 40 non-related Egyptian patients with autosomal dominant polycystic kidney disease. Patients were compared with a group of 50 healthy subjects. Human leukocyte antigen DRB1 typing was carried out on allele level (DRB1*01 — DRB1*16) using polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP). No statistically significant association of the disease with HLA-DRB1 was observed. So, HLA-DRB1 does not contribute to polycystic kidney disease in Egyptian patients.
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