CONTRIBUTION OF GENES POLYMORPHISM TO LEFT VENTRICLE HYPERTROPHY IN HIGH COMPLIANCE PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Objective: to evaluate the contribution of genes polymorphism to left ventricle hypertrophy (LVH) in high compliance patients with arterial hypertension Design and method: 144 patients with arterial hypertension. The average age was 51,72 ± 5,94 years. Patients were divided into 2 groups depending on presence of LVH been estimated using echocardiography. LVH criterion was LVMMI>115 g/sq.m in male and >95 g/sq.m in female. The 1st group consisted of 65 patients with LVH. The 2nd group included 79 patients without LVH. All the patients were examined for genotypes of the following genes: AGT Thr174Met, GNB3 C825T, MTHFR C677T, MTRR Ile22Met, ApoE Cys130Arg, PPAR G/C. α Results: Patients in the groups were equal in sex, age, comorbidities, BP level, and lipid panel parameters. In the 1st group, the rate of AGT and MTRR heterozygous polymorphism was reliably higher, than in the 2nd one: (p < 0,001 and p = 0,004 respectively). Also, in patients with LVH, both heterozygous and homozygous polymorphism of GNB3 were found more frequently (p = 0,007 and p < 0,001 respectively). There was no significant difference between the groups in MTHFR polymorphism. Correlation analysis showed direct moderate interconnection between LVH and the polymorphism of the following genes: AGT (r = 0,47; p = 0,005), GNB3 (r = 0,48; p = 0,004), MTRR (r = 0,39; p = 0,021). There was no correlation between MTHFR polymorphism and LVH. Conclusions: In high-compliance patients with arterial hypertension appearance of LVH is linearly associated with heterozygous polymorphism of AGT and MTRR genes, and with both heterozygous and homozygous polymorphism of GNB3 gene.