Abstract
BackgroundCytochrome P450 (CYPs) participate in the mechanisms of cardiovascular disease. The purpose of this research was to evaluate the contributions of CYP24A1 variants to coronary heart disease (CHD) among the Chinese Han population.MethodsThis study included 505 CHD cases and 508 controls. Four variants of CYP24A1 (rs2762934, rs1570669, rs6068816 and rs2296241) were chosen and genotyped by the Agena MassARRAY system among the Chinese population. The linkage between CYP24A1 variants and CHD risk were assessed by logistic regression to compute the odds ratio (OR) and 95% confidence interval (CI). Then, multifactor dimensionality reduction (MDR) was applied to analyze the interactions of CYP24A1 variants.ResultsThe results of this study showed that CYP24A1 rs6068816 significantly enhanced CHD risk in multiple genetic models (allele: P = 0.014; codominant: P = 0.015; dominant: P = 0.043; recessive: P = 0.040; additive: P = 0.013), whereas rs2296241 was likely to protect individuals from CHD (codominant: P = 0.019; recessive: P = 0.013; additive: P = 0.033). Stratification analysis revealed that CYP24A1 polymorphisms had strong relationships with CHD risk that were dependent on age, sex, Gensini grade and smoking status (P < 0.05). Moreover, a four-locus model (rs2762934, rs1570669, rs6068816 and rs2296241) had significant impact on CHD risk in MDR analysis.ConclusionIt revealed that CYP24A1 variants were significantly linked with CHD susceptibility in the Chinese population.
Highlights
Coronary heart disease (CHD) is a complex chronic inflammatory disease that is characterized by coronary artery remodeling and stenosis [1]
Characteristics of the study subjects were collected by medical records and questionnaires, including age, sex, smoking and alcohol use, duration of coronary heart disease (CHD), complications, and levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), uric acid (UA), urea, platelet (PLT), white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB), triglyceride (TG) and total cholesterol (TC)
Single nucleotide polymorphisms (SNP) single nucleotide polymorphism, CHD coronary heart disease, MAF minor allele frequency, OR odds ratio, 95% CI 95% confidence interval Bold-faced values indicate significant difference (P < 0.05)
Summary
Coronary heart disease (CHD) is a complex chronic inflammatory disease that is characterized by coronary artery remodeling and stenosis [1]. The World Health Organization reported that approximately 700,000 individuals die of CHD in China each year [3]. Cytochrome P450 24 subfamily A member 1 (CYP24A1) encodes a 24-hydroxylase for degrading the active form of vitamin D through multiple pathways [6, Qian et al Lipids in Health and Disease (2020) 19:181. Previous studies revealed that vitamin D deficiency is a serious factor in the progression of cardiovascular disease [8,9,10,11]. The linkage between CYP24A1 genetic variants and CHD risk in the Chinese population is not reported. Cytochrome P450 (CYPs) participate in the mechanisms of cardiovascular disease. The purpose of this research was to evaluate the contributions of CYP24A1 variants to coronary heart disease (CHD) among the Chinese Han population
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