Abstract
In our previous paper, we reported that rosmarinic acid ( 1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid ( 1) consists of two phenylpropanoids: caffeic acid ( 2) and 3-(3,4-dihydroxyphenyl)lactic acid ( 3). In this study, we investigated the structural requirements necessary for inhibition of snake venom activity through the use of compounds, which are structurally related to rosmarinic acid ( 1). By examining anti-hemorrhagic activity of cinnamic acid analogs against Protobothrops flavoviridis (Habu) venom, it was revealed that the presence of the E-enoic acid moiety (–CH CH–COOH) was critical. Furthermore, among the compound tested, it was concluded that rosmarinic acid ( 1) (IC 50 0.15 μM) was the most potent inhibitor against the venom.
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