Contribution of biological activity of some secondary metabolites of two seaweeds against some pathogenic bacteria isolated from patients in hospitals of Thi-Qar Province

Abstract

Because of their ability to generate a variety of physiologically active metabolites, seaweeds play an important role in the creation of new products for medical and pharmaceutical research. They are being studied as potential targets in the search for novel antibiotic compounds to combat antibiotic resistance. Furthermore, the use of natural antibiotics could meet customer desire for products that do not have pharmaceutical side effects.. Our results showed antimicrobial activity of two algal species Focus vesiculosus and Macrocystis pyrifera against four human pathogenic bacteria by agar well diffusion method. Four concentrations of algal extract (25, 50, 75, and 100 mg/ml) were used. It was observed that aqueous extract of Focus vesiculosus was most effective against K. pneumonia with maximum inhibition zone of 17.50 mm at 75 mg/ml, while the minimum inhibition zone (6.66mm) was found in case of K. pneumonia at concentration 50 mg/ml. In the case of aqueous and ethanolic extracts of Macrocystis pyrifera, the inhibition zone was the highest (16.16 mm) against P. aeruginosa at 50 mg/ml in aqueous extract, while the lowest inhibition zone (7.00 mm) was in case of Staphylococcus aureus at concentration 50 mg/ml.