Abstract
The present paper reports the results obtained in studying the influence of some drugs on the reticular responses and on the EEG pattern, in order to obtain data on the correlations between peripherally evoked reticular potentials, the mediation of the electrocortical arousal response and the anesthetic state. The experiments were undertaken in unanesthetized non-curarized rabbits. The response to single sciatic stimulations were recorded at various reticular levels, together with cortical and subcortical electrical activity. With pentobarbital (Nembutal) an inhibition of the reticular potential together with EEG synchronization was found, but blocking of the EEG arousal reaction to external stimulation appears before the disappearance of the reticular potential. With ether the inhibitory action of the evoked reticular response is connected to the anesthetic state, but is independent from cortical synchronization. On the other hand with scopolamine, it is possible to obtain an EEG synchronization with blocking of arousal to external stimuli without impairment of the reticular response to single sciatic shock. It seems reasonable to assume that the anesthetic state is not necessarily related to the slowing of EEG activity, blocking of the EEG “arousal response” or alteration of the reticular response to single sensory stimulation.
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