Abstract
Complex lymphatic anomalies (CLAs) are rare, pediatric developmental lymphatic anomalies that include a spectrum of overlapping clinical presentations, imaging findings, and symptoms. Owing to their rarity, diagnosis and treatment can be challenging. CLAs have significant risk of morbidity and mortality and require multimodal, comprehensive management. New molecular insights into the pathogenesis of CLAs will likely change classification and therapeutic options in the future. We describe herein 2 children with CLAs with distinct presentations and clinical courses but with some overlapping features. These cases highlight the spectrum of disease presentation in CLAs as well as the need for continued use of molecular data to drive diagnosis, classification, and management of these rare disorders.
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