Contrasting Ability of Steroidal (ICI 182 780) and Non-steroidal (EM-800) Antiestrogens to Inhibit Reproductive Organ Growth in Male and Female Mice

J Škarda,E Köhlerová,J Kotanová

doi:10.2754/avb200574040533

Abstract

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Highlights

We show that ICI behaves as an antiestrogen in the mammary gland, uterus and seminal vesicles of animals treated with Prog or E
The intrinsic estrogenic activity of EM was demonstrated in the mammary gland and uterus of Prog treated adult OVX females and in seminal vesicles of E treated young intact males
Contrary to EM, ICI always decreased mammary growth, uterine weight and increased seminal vesicle growth under similar conditions, showing no intrinsic estrogenic activity in mice as it was demonstrated in rats, pigs, monkey and woman (Wakeling et al 1991; Dukes et al 1993; Branham et al 1996; Thomas et al 1996; Tarleton et al 1999)

Summary

Introduction

All estrogenic compounds do not produce the same conformation of receptors, and the ability of ligand-bound receptors to regulate target gene transcription is determined by the cell- and tissue- specific expression of both different coactivator and corepressor proteins that impact the ER signalling pathway (Paige et al 1999). Adding to this complexity there are two ER subtypes – ER α and ER β (Kuiper et al 1996).

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