Abstract
To assess the effect of low-osmolar, monomeric contrast media with different iodine concentrations on bolus shape in aortic CT angiography. Repeated sequential computed tomography scanning of the descending aorta of eight beagle dogs (5 male, 12.7±3.1kg) was performed without table movement with a standardized CT scan protocol. Iopromide 300 (300mgI/mL), iopromide 370 (370mgI/mL) and iomeprol 400 (400mgI/mL) were administered via a foreleg vein with an identical iodine delivery rate of 1.2gI/s and a total iodine dose of 300mgI/kg body weight. Time-enhancement curves were computed and analyzed. Iopromide 300 showed the highest peak enhancement (445.2±89.1 HU), steepest up-slope (104.2±17.5 HU/s) and smallest full width at half maximum (FWHM; 5.8±1.0s). Peak enhancement, duration of FWHM, enhancement at FWHM and up-slope differed significantly between iopromide 300 and iomeprol 400 (p<0.05). Except for enhancement at FWHM there were no significant differences between iopromide 300 and iopromide 370 and iopromide 370 and iomeprol 400 (p>0.05). Low viscous iopromide 300 results in a better defined bolus with a significantly higher peak enhancement, steeper up-slope and smaller FWHM when compared to iomeprol 400. These characteristics potentially affect contrast timing.
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