CONTRAST-INDUCED NEPHROPATHY;

Abstract

Introduction: Contrast induced nephropathy (CIN) is a disorder characterizedby the onset of acute renal failure within 24 to 72 hours after the administration of iodinatedcontrast medium after coronary angiography. CIN is associated with prolonged hospitalizationand adverse clinical outcomes. The objective of this study is to determine the frequency ofcontrast induced nephropathy in patients of coronary artery disease undergoing coronaryangiography in local population. Setting: Department of Cardiology, Faisalabad Instituteof Cardiology. Period: 16-04-2016 to 15-10-2016. Subjects and Methods: 200 patients ofcoronary artery disease booked for coronary angiogram. Study design was Cross-sectional.Baseline characteristic and history of risk factors of coronary artery disease were noted. Serumcreatinine level was recorded at baseline and after 48 hours of angiography by sending bloodsample to the hospital pathology department and were noted. Contrast induced nephropathywas assessed. Results: Mean age of the patients was 53.61±12.48 year. Patients with agebetween 30-50 years were 76(38%) and patients with age 51-70 years were 124 (62%). Outof 200 patients, 130 (65%) were males while remaining 70 (35%) were females. In the studypopulation 14 (7%) developed contrast induced nephropathy (CIN). Mostly patients of 51-70years of age group developed CIN. CIN was reported in 9(6.92%) male patients and 5(7.1%)female patients. Among diabetic 4 (3.57%) patient developed CIN. Among hypertensive patients2 (2.77%) patient developed CIN. Similarly in patients presented with acute coronary syndrome8 (7.61%) patient developed CIN. Conclusion: In conclusion, contrast induced nephropathy inpatients with coronary artery disease undergoing coronary angiogram was found in 7%. CIN isa relative common finding following coronary angiography in patients especially in elderly andmale patients. More incidences of CIN were noted in patients presented with acute coronarysyndrome and in diabetic patients.