Contrast induced nephropathy after percutaneous coronary intervention: Observational Study

Abstract

The incidence of Contrast-induced nephropathy (CIN) varies because of differences among the published studies in the definition of CIN, the proportion of high-risk patients, the types of contrast media, and the use of preventive measures. The purpose of our study was to determine the incidence of CIN among patients admitted for ST-Elevation Myocardial Infarction (STEMI) in the department of cardiology of Nabeul Hospital Center. Eighty patients were included. All the patients were admitted for a STEMI in the cardiology department of Nabeul Hospital Center from January 2020 to June 2020. The overall pooled CIN incidence was 8% The forest plots showed positive associations between CIN and the presence of hypertension, diabetes mellitus, history of prior myocardial infarction, age, stenosis of left anterior descending artery, Killip class ≥ 2, decreased left ventricular ejection fraction, lower estimated glomerular filtration rate, and left ventricular ejection fraction < 40%. At a median follow-up of 12 months, major cardiovascular events including cardiovascular death, reinfarction, and stroke were more frequents in patients with CIN (12.5% vs. 2.5%, P -value < 0.001). Contrast-induced nephropathy is common after PCI in patients with STEMI and always leads to a poor prognosis. It is associated with increased rate of cardio-vascular complications at medium and long-term follow-up.