Abstract
The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer (verteporfin) dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue. An orthotopic pancreatic xenograft mouse model was used for the study. A strong correlation (r = 0.57) was found for bulk intensity measurements of T1-weighted gadolinium enhancement and verteporfin fluorescence in the tumor region of interest. The use of contrast-enhanced MR imaging shows promise as a method for treatment planning and photosensitizer dosimetry in human photodynamic therapy (PDT) of pancreas cancer.
Highlights
The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue
photodynamic therapy (PDT) for pancreatic cancer (PaC) involves the injection and uptake of verteporfin within tumor tissue followed by activation of the drug using 690-nm light delivered through interstitial optical fibers
An orthotopic xenograft (AsPC-1) murine model (n 1⁄4 7) for PaC PDT was used in accordance with the policies and approved protocol of the Institutional Animal Care and Use Committee (IACUC) at Dartmouth College.[5]
Summary
The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer (verteporfin) dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue. The axial T2W-TSE image sequence was selected for the tissue-slicing plane and the coronal T2W-TSE was used to align the image scans with the outermost edge of the tumor, termed the tumor origin [Fig. 1(a)].
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