Abstract
Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications. Here we show that high-resolution (HR) DOT is also advantageous for clinical perfusion imaging using an optical contrast agent. We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent. We find an early arrival of the ICG bolus in the intracerebral tissue and a delayed arrival of the bolus in the extracerebral tissue, achieving the separation of both layers. This demonstrates the method’s potential for brain perfusion monitoring in neurointensive care patients.
Highlights
In neurointensive care, bedside monitoring of brain perfusion or perfusion based therapies is desirable to evaluate the patient’s pathologic state and to guide treatment
Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications
We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent
Summary
Bedside monitoring of brain perfusion or perfusion based therapies is desirable to evaluate the patient’s pathologic state and to guide treatment. Previous NIRS studies of brain perfusion using indocyanine green (ICG) focused on the measurement of cerebral blood flow (CBF) and cerebral blood volume (CBV) [1,2] or differences of bolus kinetics in affected and unaffected hemispheres in stroke patients [3,4]. All these studies employed a topographic NIRS approach, which uses next-nearest neighbor measurements of optical fibers that are separated up to 5 cm. That’s why methods are needed that are able to differentiate between tissue depths and that assess the contribution of the signal that originates from the brain
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