Abstract

With increasing use of myocardial biopsy as a diagnostic tool, different criteria of pathology have evolved from tissues obtained from biopsy and post mortem specimens. Since contraction bands have been present in myocardial tissue associated with various cardiac pathological states, their presence have been interpreted as being a part of these pathological processes. For example, CB have been used as a morphological index of pathology in conditions such as ischemia, cardiomyopathy, and catecholamine toxicity. We recently reported that contraction bands may be produced artifactually by the biopsy procedure in the fresh, but not the post mortem or perfused fixed normal rat heart (1). In order to establish the generality of these results we undertook the present study,the aim of which was to determine the incidence and significance of CB in biopsies from the normal human heart.Biopsy specimens were obtained from twelve normal young individuals who had recent irreversible traumatic damage to their brain.

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