Abstract
Chronic kidney disease is a public health problem with increasing prevalence caused by diabetes, hypertension and glomerulonephritis. Number of publications investigate the lower urinary tract dysfunction due to CKD is limited. There is a high incidence of bladder dysfunction of different degrees in patients with renal failure. Mechanism of the lower urinary tract dysfunction in these patients is not well known. In this study, we aimed to investigate the effects of CKD on detrusor function in a rat model of CKD. In our study, 20 Wistar Albino rats have been divided into two groups as CKD and control groups. To the experiment group, left partial nephrectomy and right nephrectomy have been applied. CKD confirmation has done with the BUN and creatinin values from the blood of the rats. The bladder strips were prepared from the CKD and control groups and its contractile responses were evaluated in-vitro. There wasn't a considerable difference with the contractile responses caused by carbachol, KCL. There was a considerable increase in the contractile responses caused by ATP, ADP and electrical field stimulation on the behalf of the CKD group. The present study demonstrated that isolated DSM of CKD group showed significantly increased contraction responses to purinergic agonists ADP, ATP and atropine resistant component in electrical field stimulation-induced contractions as compared to those of the control group. Bladder overactivity and reduced bladder volume in CKD patients might be due to the change in purinergic system.
Highlights
The term lower urinary tract symptoms (LUTS) is universally recognized as the preferred terminology to describe a constellation of symptoms that may be caused by multiple pathologic conditions
The present study demonstrated that isolated detrusor smooth muscle (DSM) of chronic kidney disease (CKD) group showed significantly increased contraction responses to purinergic agonists ADP, adenosine triphosphate (ATP) and atropine resistant component in electrical field stimulation-induced contractions as compared to those of the control group
Contractile studies Isolated bladder strips which obtained from control and CKD groups were treated with mM KCl and responses received by KCL graphed; checked the contractility of strips before and after performing the contractile studies
Summary
The term lower urinary tract symptoms (LUTS) is universally recognized as the preferred terminology to describe a constellation of symptoms that may be caused by multiple pathologic conditions. Submitted: 16 April 2012 / Accepted: 20 July 2012 drome, pelvic organ prolapse, urinary tract infection, neurologic conditions, oncologic diseases, diabetes mellitus, metabolic syndrom and chronic kidney disease (CKD). Chronic kidney disease is a public health problem with increasing prevalence caused by diabetes, hypertension and glomerulonephritis [ ]. Causal connection between lower urinary tract dysfunction with CKD is well-known especially in pediatric population but number of publications investigate the lower urinary tract dysfunction due to CKD is limited. Mechanism of the lower urinary tract dysfunction in these patients is not well known. We aimed to investigate the effects of CKD on detrusor function in rat model of CKD
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