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Abstract
Present means of contraception are not satisfactory for all women. This study reports on the contraception efficacy and menstrual abnormalities of medroxyprogesterone acetate (Depo-Provera), which was given in an intramuscular dose of 150 mg. every 3 months for 1 year. None of the 14 patients who received the full 12 months of therapy became pregnant. The occurrence of spotting and bleeding was erratic, but each tended to decrease as the treatment continued. After cessation of treatment, most patients had two or three “normal menstrual periods,” which biopsy proved to be from a proliferative endometrium. All patients had a secretory endometriurn within 12 months after the last injection, or within 9 months after the effects of the last injection had presumably worn off. Irregular bleeding, spotting, and relatively prolonged anovulation are the main disadvantages of this form of therapy. The chief advantage is the infrequent need for injection; patients need to be concerned with birth control only 1 day every 3 months.
Published Version
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