Abstract
The combined oral contraceptive containing 20 μ g of ethinylestradiol and 3 μ g of drospirenone is an effective contraception method with the optimum shortened hormone-free interval and good tolerance predetermined by the positive effect on the body weight, lipid metabolism, general state and symptoms related to liquid retention and hyperandrogenism. The data obtained in in vitro and in vivo studies about the role of drospirenone in blocking of adipocyte differentiation and triglyceride accumulation as well as about regulation of the white fat remodeling justify possible effects of this drug on prevention of negative metabolic consequences of the adipocyte dysfunction. Results of clinical studies are indicative of the body weight reduction and positive effect on the lipid profile without statistically significant effect on insulin sensitivity, which leads to high degree of the women satisfaction with this type of contraception.
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