Contraception continuation among female exotic dancers seeking mobile reproductive health services concurrent with syringe exchange

Abstract

s / Drug and Alcohol Dependence 140 (2014) e86–e168 e135 Contraception continuation among female exotic dancers seeking mobile reproductive health services concurrent with syringe exchange Caitlin E. Martin1, Mishka Terplan2, J. Han3, P. Chaulk4, C. Serio-Chapman3 1 Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD, United States 2 Departments of Obstetrics, Gynecology, and Reproductive Sciences & Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States 3 Community Risk Reduction Services, Baltimore City Health Department, Baltimore, MD, United States 4 Bureau of HIV/STD Services, Baltimore City Health Department, Baltimore, MD, United States Aims: Female exotic dancers are an understudied population with a high prevalence of drug and alcohol use, risk factors for transactional sex and inconsistent condom use. In 2009, the Baltimore City Health Department expanded their mobile syringe exchange program to include reproductive health services in the “Red Light” district. The objective of this study was to describe depot medroxyprogesterone acetate (Depo-Provera) continuation patterns among female exotic dancers seeking these mobile health services. Methods: We performed a retrospective analysis of 75 clients who initiated Depo-Provera at a mobile health clinic attached to a syringe exchange from November 2009 to August 2012. Demographics, Depo-Provera uptake and continuation over 12 months were assessedby chart review. Characteristics between clientswho continued Depo-Provera at 3 months and those who did not were compared using chi-square and t-tests. Results: Seventy-two percent (N=52) of clients were African American, and 62% (N=42) were 24 years or younger. At 3 months, 36% (N=25) continued Depo-Provera. Clients who were Caucasian (p=0.03) and received other reproductive health services (p<0.01) were more likely to continue. At 6 and 12 months, 29% and 7% of all clients who initiated Depo-Provera continued, while successive continuation rates for those receiving the previous injection were higher at 54% and 63%. Conclusions: Continuation of Depo-Provera among female exotic dancers is similar to that of the general population, with low overall but higher successive continuation after 3 months. Our study illustrates that integrating mobile reproductive health services into a needle exchange program can help fulfill the unique health needs of this high-risk population. Financial support: None. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.383 9-tetrahydrocannabinol does not substitute in rats trained to self-administer WIN55212-2 Julie A. Marusich, T. Lefever, J. Wiley Discovery & Analytical Sciences, RTI International, Research Triangle Park, NC, United States Aims: Although THC i.v. self-administration has been demonstrated in nonhuman primates, establishing THC selfadministration in rodents has proven difficult. In contrast, self-administration of a synthetic cannabinoid, WIN55212-2 (WIN), in rats has been reported. The purpose of this study was to examine if rats trained to self-administer WIN would also self-administer THC. Methods: Male Long-Evans rats were trained to self-administer cocaine (COC; 0.03mg/kg/infusion) or WIN (0.01mg/kg/infusion) through autoshaping. Rats were thenmaintained on a fixed ratio 3, with 3 priming infusions given at the beginning of each 3h session. Dose-effect curves of the training drugs were assessed followed by pretreatment with rimonabant. Dose–effect curves were then determined for WIN in the COC group, and THC in the WIN group. Results: Rats self-administered COC and WIN at levels significantly above vehicle. Rimonabant decreased responding for both drugs. When WIN was substituted for COC, rats did not acquire self-administration of WIN. Similarly when THC was substituted for WIN, rats did not acquire self-administration of THC. Conclusions: Themethodsusedhereproduced similar amounts of WIN intake compared to previous studies in rats; however, THC did not substitute for WIN. Between subject variability was high for both WIN and THC. Given the typical within class substitution observed in previous self-administration studies, these results suggest that the reinforcing effects of WIN and THC differ in rats. In previous research, establishing self-administration of other drug classes (e.g. stimulants) has also been largely unsuccessful in producing THC self-administration. Similarly, in the present study rats with a history of COC self-administration did not self-administer WIN, suggesting that exposure to a more reinforcing drug may decrease the likelihood of self-administration of cannabinoids, or that substitution across drug classes is not a reliable method for assessing abuse liability for cannabinoids. Financial support: RTI International internal research and development funds and NIDA Grants DA-03672 and DA-031988. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.384 Binge alcohol consumption in emerging adults: Altered anterior cingulate cortical thickness is associated with alcohol use consequences Yasmin Mashhoon1,3,4, C. Czerkawski2, D.J. Crowley1,2,4, J.E. Cohen-Gilbert1,2,4, J.T. Sneider1,2,4, M.M. Silveri1,2,4 1 McLean Imaging Center, McLean Hospital/HMS, Belmont, MA, United States 2 Neurodevelopmental Lab, McLean Hospital/HMS, Belmont, MA, United States 3 Behavioral Psychopharmacology Research Lab, McLean Hospital/HMS, Belmont, MA, United States 4 Psychiatry, Harvard Medical School, Boston, MA,