Continuous wavelet transform analysis of blood flow for the determination of hyper and hypo glycemic conditions

Abstract

Abstract A new experimental laser setup has been designed to perceive the distinguishing features between total and superficial skin. The selectivity of which is based on wavelength affecting the penetration depth into the skins. The optical property of blood depends strongly on physiological parameters such as oxygen saturation, osmolarity, flow conditions, and hematocrit. As media for light propagation, most human tissue is considered as turbid. Turbid tissues are heterogeneous structures and correspondingly have spatial variations in their optical properties. The spatial variation and density of these fluctuations make these tissues strong scatterers of light. In the absence of absorption, a significant fraction of the photons launched into these tissues are scattered multiple times, giving rise to a diffuse and largely incoherent field of penetrating light. The continuous wavelet transform technique, a time-frequency method with logarithmic frequency resolution is used to analyze blood flow in human peripherals. The blood circulation was measured by laser Doppler flowmetry. The blood flow oscillations extended over a wide frequency scale and their periods varied with time. Within the range of frequency 0.02 Hz to 0.06 Hz is studied and revealed, arising from both local and central regulatory mechanisms. In this way it is demonstrated that endothelial activity is a rhythmic process that contributed to oscillations in blood flow with one of the characteristic frequencies. This illustrates the study of the potential about laser Doppler flowmetry combined with dynamical systems analysis for studies of the microcirculation mechanisms of blood flow regulation in vivo.