Abstract
Purpose The efficacy of continuous versus intermittent bladder irrigation with amphotericin B in the treatment of candiduria was compared. Materials and Methods A prospective, randomized and comparative pilot study was done on 20 patients. Continuous bladder irrigation with 50 mg./l. amphotericin B infused during 24 hours for 2 days was compared to 3 intermittent bladder irrigations of 10 mg./100 ml. amphotericin B in 1 day. Urine cultures were obtained 72 hours after treatment. Results The organism was eradicated in 8 patients (80 percent) who received continuous irrigation and 3 (30 percent) who received intermittent irrigation (p = 0.035). Conclusions Continuous amphotericin B bladder irrigation was superior in terms of efficacy, ease of administration and patient comfort.
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