Abstract
Metformin is frequently used by type II diabetics. A rare complication of its use is metformin associated lactic acidosis (MALA). This condition is often accompanied by extreme metabolic acidosis and hemodynamic instability for which ICU treatment is mandatory. Guidelines advice intermittent hemodialysis for correction of metabolic acidosis and to clear metformin. However, haemodynamic instability may prefer continuous veno-venous hemofiltration (CVVH). We evaluated the effect of CVVH in critically ill patients admitted with MALA.
Highlights
Metformin is frequently used by type II diabetics
All consecutive patients admitted with clinical diagnosis of metformin intoxication between January 2010 and December 2014 were included
continuous veno-venous hemofiltration (CVVH) was administered in high volume post-dilution mode with citrate anticoagulation
Summary
Metformin is frequently used by type II diabetics. A rare complication of its use is metformin associated lactic acidosis (MALA). Methods We performed a retrospective single centre cohort study in a 20-bed mixed ICU. All consecutive patients admitted with clinical diagnosis of metformin intoxication between January 2010 and December 2014 were included. Data were extracted from the local Patient Data Management System and analysed with SPSS 21.0.
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