Abstract
A model is developed for simulating continuous manufacturing of β-lactam antibiotics by enzymatic reactive crystallization. An amoxicillin case study using the unified model of reaction and crystallization kinetics in different reactor designs is presented. Attainable regions are constructed for conversion of amoxicillin precursors and mean crystal size. Attainable regions for conversion show that, with a 2:1 molar ratio of precursors, 98% conversion of the limiting reactant is possible with reactive crystallization while only 72% conversion can be achieved without crystallization. A well-mixed reactive crystallizer is shown to have higher productivity than a plug-flow reactive crystallizer, which is uncommon for positive-order processes like enzyme reactions and crystallization. A Pareto optimal surface is drawn for conversion, productivity, and fractional yield to inform the design of an optimal process. Additional means of optimizing production of amoxicillin, including classified crystal fines removal, are discussed to further enhance crystal size and productivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.