Continuous prediction of glucose-level changes using an electronic nose in critically ill patients

JH Leopold,A Abu-Hanna,LD Bos,RT Van Hooijdonk,PJ Sterk,MJ Schultz,T Winters

doi:10.1186/cc13627

Abstract

Many if not most critically ill patients are treated with insulin during their stay in the ICU [1]. Intensive monitoring of the blood glucose level is a prerequisite for efficient and safe insulin titrations in these patients [2]. Current continuous glucose measurement techniques rely on subcutaneous glucose measurements [3] or measurements in blood [4]. We hypothesized that changes in volatile organic compound (VOC) concentrations in exhaled breath reflect changes in the blood glucose level. Changes in VOC concentrations can be analyzed continuously using a so-called electronic nose (eNose) [5]. Our aim was to investigate exhaled breath analysis to predict changes in glucose levels in intubated ICU patients.

Highlights

We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety
There are numerous reports of critical care staff stealing controlled drugs (CDs) for personal use or financial gain and notably there have been some cases where CDs have been substituted for other medications in order to delay detection of the theft
Pediatric pharmacists have been an integral part of the PICU rounds since 2002, their role has evolved over the course of years

Summary

Introduction

We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety. The objective of our study was to implement a Post Arrest Consult Team (PACT) and improve the quality of care for admitted OHCA patients This retrospective audit evaluated adult patients who suffered in-hospital cardiac arrest (IHCA) against the recent National Confidential Enquiry into Patient Outcome and Death (NCEPOD) report [1]. It looked at the recognition of the acutely unwell, the interventions made, the decisions taken from admission through to the post-arrest period and the outcomes following cardiopulmonary resuscitation (CPR). Methods We conducted a chart review of all patients admitted to the Department of Critical Care (DCC) at our hospital following cardiac arrest over 2 years in 2010 to 2012 (Group 1). Methods A retrospective review was conducted looking at SICU patients managed with a normothermia protocol, with particular

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Conclusion