Abstract
Continuous positive airway pressure (CPAP) consequences on right heart function and serum biomarkers in obstructive sleep apnea assessed by tricuspid annular plane systolic excursion (TAPSE) and color tissue doppler imaging
Highlights
Numerous cross-sectional studies have demonstrated an association between severe obstructive sleep apnea syndrome Obstructive Sleep Apnea (OSA) and increased cardiovascular mortality and morbidity [1,2,3,4,5,6]
Beyond Continuous Positive Airway Pressure (CPAP) adherence predicting decreased mortality and morbidity for population studies, there are no earlier predictors of long term cardiovascular protection or benefit for individual patients [31,32]
Serum leptin elevation has been shown as an independent predictor of OSA [33] which is reversible with OSA treatment [35]
Summary
Numerous cross-sectional studies have demonstrated an association between severe obstructive sleep apnea syndrome OSA and increased cardiovascular mortality and morbidity [1,2,3,4,5,6]. This is especially true when OSA coexists with hypertension, atrial fibrillation, coronary artery disease or congestive heart failure [5,7,8,9]. Animal models clearly demonstrate progressive cardiovascular dysfunction in the setting of severe sleep apnea Epidemiologic studies by their nature have left us with only modest correlations at best. Right ventricular (RV) dysfunction without overt right heart dilation has been identified as a finding in OSA that may precede deterioration of left heart function [10,11,12]
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