Abstract
We set out to investigate whether continuous negative abdominal pressure (CNAP) might be used to decrease abdominal pressure. We investigated the effects of CNAP on both intra-abdominal pressure (IAP) and central venous pressure (CVP) on 30 consecutive patients admitted to our ICU (age 62 ± 14 years, BMI 26.3 ± 4, SAPS II 40.4 ± 18). Patients with severe hemodynamic instability and/or with recent laparotomy were not studied. Measurements included bladder pressure as an index of IAP, CVP, invasive mean arterial pressure (APm) and heart rate (HR). Following baseline measurements (Basal), CNAP (Life Care – Nev 100, Respironics) was applied on the abdomen at three levels: CNAP =, CNAP -5 and CNAP -10, corresponding to negative pressure equal to baseline IAP, 5 or 10 cmH2O lower than CNAP =, respectively. Results are as presented in Table Table11. Table 1 CVP was correlated with IAP (R2 = 0.790, P < 0.001, multiple linear regression). Given these results, we conclude that CNAP decreases IAP and CVP; the higher the negative pressure applied, the greater the changes. CVP decreases possibly because of a blood shift from the intrathoracic compartment.
Highlights
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis
We sought to compare differences in mortality and length of stay (LOS) between lactic acidosis (LA) and other forms of metabolic acidoses. In this observational pilot study, we reviewed records of 9799 patients admitted to the intensive care unit (ICU) at our institution between
Multiple Organ Failure (MOF) complicating the sepsis remains the first cause of death in the ICU
Summary
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis. (recombinant human activated protein C [rhAPC]) in modulating microvascular coagulation through the inhibition of thrombin generation has been well studied in experimental and clinical settings of severe sepsis, little is known about its direct anti-inflammatory effects on vascular endothelial cells. We retrospectively examined the demographics, risk factors, baseline characteristics, and outcomes of patients initially treated in an intensive care unit (ICU) enrolled in a randomized study of CAS vs AmB for IC. The aim of this study was to analyze in brain-injured patients during mechanical ventilation: 1) the incidence of pulmonary infection (P.I.), diagnosed by cultural data of bronchoalveolar lavage (> 104 cfu/ml); 2) predisponent factors of P.I.; 3) the prevalence of sepsis and severe sepsis criteria [2]; 4) the association with morphological alterations of chest X-ray, respiratory failure The aim is to determine whether an effective lifestyle adaptation program post CABG could enhance the quality of life of the CABG patient
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