Continuous intravenous infusion of low dose of ketamine combined with morphine used for postoperative analgesia in patients undergoing abdominal gynecological surgery

Abstract

Objective To explore the effect and the side-effect of continuous intravenous infusion of low dose of ketamine combined with morphine for postoperative analgesia in patients undergoing abdominal gynecological surgery.Methods Ninety patients undergoing abdominal gynecological surgery were randomly divided into three groups,group Ⅰ(morphine,0.02 mg/kg),group Ⅱ(morphine,0.15 mg/kg+ ketamine, 0.04 mg/kg),and group Ⅲ(morphine, 0.15mg/kg+ketamine, 0.06 mg/kg),to accept intravenous postoperative analgesia. The pain scores of VAS,sedation scores,the incidence of side effects including pruritus, nausea and vomiting were recorded at 6,12,24,36,48 h after operation. Results The pain score of group Ⅲ at each time point was significantly lower than that of group Ⅰ and group Ⅱ(P 0.05).There was no significant difference among the three groups on sedation scores(P>0.05),and the incidence of the nausea and vomiting and pruritus were significant higher in group Ⅰ than that in group Ⅱ and group Ⅲ(P<0.05). Conclusions 0.06 mg/kg of ketamine can enhance the effect of morphine,lower the comsumption dosage of morphine,and decrease side-effect events. Key words: Low dose of ketamine; Morphine; Postoperative controlled analgesia; Gynecological surgery