Continuous Intravenous Anesthesia with Etomidate for Carbon Dioxide Laser Surgery of the Larynx

Abstract

Twenty-five adult patients undergoing carbon dioxide laser surgery for benign and malignant disease of the larynx were given continuous infusion of etomidate at 60μg·kg−1-min−1 for induction of anesthesia. Maintenance anesthesia was continued using one of three infusion rates: 20μg·kg−1·min−1 (n = 5), 30μg·kg−1·min−1 (n = 10), and 40 μg·kg−1·min−1 (n = 10) of etomidate in air-oxygen mixture. Muscular relaxation was achieved by continuous infusion of succinylcholine, and fentanyl was used for analgesia. Continuous etomidate infusion for induction of anesthesia resulted in a significant decrease in the incidence of pain along the injection site to 8% and involuntary muscular movements to 12% compared with 36% and 44%, respectively, in a group of 25 adult patients undergoing endoscopic procedure who received intravenously a single bolus injection of etomidate (0.3 mg·kg−1). However, a prolonged recovery time was observed after 30 minutes of continuous etomidate infusion.