Abstract
Hydrogenation still faces unmet technical challenges in relation to heterogeneous reactions and potential safety issues. In this work, a continuous flow Pd/C-catalyzed hydrogenation of 2-(4-nitrophenyl) butanoic acid (NBA) was developed within a micropacked-bed reactor. Catalytic hydrogenation of NBA involves the interaction of gaseous and liquid reactants on solid catalysts and the mechanism has not been clearly reported. Therefore, the Langmuir-Hinshelwood-Hougen-Watson (LHHW) approach was used to investigate the kinetics and attempted to explain the possible mechanistic path. The effects of internal diffusion, external diffusion, and salt formation were characterized, the intrinsic kinetic model was established and corresponding parameters were obtained. The model showed that the reaction proceeds through the dual site molecular adsorption of reactant specie and NBA can be reduced to 2-(4-aminophenyl) butanoic acid (ABA) either through the generation of hydroxylamine intermediates or directly.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
