Abstract
Sepsis, and its major lethal sequelae of shock and multiple system organ failure (MOF), is the most common cause of death in the intensive care unit (ICU). Sepsis results from a metabolic derangement, leading to cardiovascular failure and (sequential) organ dysfunction, ultimately resulting in MOF [1,2]. Initial resuscitation aims to restore tissue perfusion with volume loading and vasopressor support, guided by assessment of the patients hemodynamic status and early intervention to compensate for specific organ failure (including artificial Ventilation). Identification of the site infection and choice of appropiate antibiotics are critical to the successful therapy [2,3]. However, despite this aggressive ICU management, mortality from septic shock remains unacceptably high at approximately 60% [1,2].
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