Abstract

Aims/hypothesisThe aim of this study was to analyse patterns of continuous glucose monitoring (CGM) data for associations with large for gestational age (LGA) infants and an adverse neonatal composite outcome (NCO) in pregnancies in women with type 1 diabetes.MethodsThis was an observational cohort study of 186 pregnant women with type 1 diabetes in Sweden. The interstitial glucose readings from 92 real-time (rt) CGM and 94 intermittently viewed (i) CGM devices were used to calculate mean glucose, SD, CV%, time spent in target range (3.5–7.8 mmol/l), mean amplitude of glucose excursions and also high and low blood glucose indices (HBGI and LBGI, respectively). Electronic records provided information on maternal demographics and neonatal outcomes. Associations between CGM indices and neonatal outcomes were analysed by stepwise logistic regression analysis adjusted for confounders.ResultsThe number of infants born LGA was similar in rtCGM and iCGM users (52% vs 53%). In the combined group, elevated mean glucose levels in the second and the third trimester were significantly associated with LGA (OR 1.53, 95% CI 1.12, 2.08, and OR 1.57, 95% CI 1.12, 2.19, respectively). Furthermore, a high percentage of time in target in the second and the third trimester was associated with lower risk of LGA (OR 0.96, 95% CI 0.94, 0.99 and OR 0.97, 95% CI 0.95, 1.00, respectively). The same associations were found for mean glucose and for time in target and the risk of NCO in all trimesters. SD was significantly associated with LGA in the second trimester and with NCO in the third trimester. Glucose patterns did not differ between rtCGM and iCGM users except that rtCGM users had lower LBGI and spent less time below target.Conclusions/interpretationHigher mean glucose levels, higher SD and less time in target range were associated with increased risk of LGA and NCO. Despite the use of CGM throughout pregnancy, the day-to-day glucose control was not optimal and the incidence of LGA remained high.

Highlights

  • Despite improved glycaemic control, the prevalence of macrosomia and large for gestational age (LGA) remains high in babies born to women with type 1 diabetes, affecting approximately one-half of these newborn infants [1,2,3]

  • Electronic supplementary material (ESM) Table 1 shows the number of women and the number of measurements made in the total cohort according to the glucose monitoring system used

  • In this study, using continuous glucose monitoring (CGM)-derived measures to describe glucose control, we found that mean glucose levels, SD of mean glucose levels, and time spent in and outside the target range (3.5– 7.8 mmol/l) during the second and third trimesters were the most important predictors of LGA and neonatal outcomes

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Summary

Introduction

The prevalence of macrosomia and large for gestational age (LGA) remains high in babies born to women with type 1 diabetes, affecting approximately one-half of these newborn infants [1,2,3]. Fetal exposure to maternal hyperglycaemia is thought to be the major determinant of fetal overgrowth in pregnancies in women with type 1 diabetes [9]. The overarching goal of prenatal care in these women is to achieve near normal glycaemic control, usually estimated by self-monitoring of plasma glucose and HbA1c. HbA1c may not adequately reflect fetal glycaemic exposure as it represents an average measure of glycaemic control in the preceding 2– 3 months and does not capture acute glucose fluctuations or intra- and inter-day glycaemic variability [10,11,12]. Recent data have shown that fewer than 50% of pregnant women with diabetes in the UK reach target HbA1c levels [15]

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