Abstract
Many patients with type 2 diabetes mellitus (T2DM) are on insulin analogues which are costly as well as usage of higher units of insulin on a daily basis increases the cost of the monthly therapy. Concentrated insulin are a way forward for patients who needs higher units of insulin especially Human insulin which address the issues of higher cost and the need for higher concentration in the same or lesser volume of insulin. However, data on 24-hour glycemic control with concentrated insulin in Indian T2DM patients are limited. Hence, this study was conducted to study 24-hour glycemic control in T2DM patients treated with U-200 by measuring the variability in 24-hr blood glucose profile measured using a continuous glucose monitoring (CGM) device over 6 days.
Highlights
Of the worldwide 415 million people with diabetes, India is home to 69.1 million cases, representing approximately 6% of the global population with diabetes [1]
U200 insulin led to less glycemic variability, minimal hypoglycemia and efficient glucose control in Indian type 2 diabetes mellitus (T2DM) patients
Patients with modification of concomitant oral anti-diabetic (OAD) medicines regimens or insulin dose in past three months, patients treated with Sulfonylureas, Meglitinide derivatives in last 1 month, history of recurrent hypoglycemic episodes or event of severe hypoglycemia or diabetic ketoacidosis/hyperglycemic hyperosmolar coma in past three months, diabetes related moderate to severe complications, history of surgery, severe trauma, infection or hospitalization in past six months, pregnant and lactating women were excluded from the study
Summary
Of the worldwide 415 million people with diabetes, India is home to 69.1 million cases, representing approximately 6% of the global population with diabetes [1]. Higher levels of free fatty acids in patients with central obesity increase the need of more insulin production and predisposes patient to insulin resistance [2]. Obesity and its associated insulin resistance have contributed to increased prevalence of T2DM and to a rise in the insulin needs of insulin requiring patients with T2DM. Despite the availability of several anti-diabetic agents, most patients with T2DM need addition of insulin in their treatment regimen [2]. Many patients with type 2 diabetes mellitus (T2DM) are on insulin analogues which are costly as well as usage of higher units of insulin on a daily basis increases the cost of the monthly therapy. Data on 24-hour glycemic control with concentrated insulin in Indian T2DM patients are limited. This study was conducted to study 24hour glycemic control in T2DM patients treated with U-200 by measuring the variability in 24-hr blood glucose profile measured using a continuous glucose monitoring (CGM) device over 6 days
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