Abstract
The chronically-prepared gut is a very useful model for the determination of the motor profile changes due to drugs in both fed and fasted animals. Rats fitted with strain gauge transducers and implanted electrodes showed a good relationship between motility indices of spiking activity and mechanical activity. In both fed and fasted rats records of contractions of the antrum gave a more accurate representation, as tonic changes in antrat activity can be seen. On the other hand, the electrical spiking activity of the small intestine allows more accurate recording of pharmacological responses than recording of the mechanogram. These variations as well as the changes in the duration of quiescence may be of importance in the quantitative assessment of the gastrointestinal motor profile.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
