Continuous administration of 5-hydroxytryptamine alters cellular immunity in chickens

Abstract

1. 5-Hydroxytryptamine administered continuously through osmotic pumps altered the PHA wattle response and in vitro leukocyte capillary tube migration in UNH 105 chickens. 2. Administration of 100 ng/hr 5-hydroxytryptamine for 48 hr significantly suppressed the PHA wattle response. 3. In vitro leukocyte migration was significantly enhanced by 72 hr exposure to 5-hydroxytryptamine at a dose of 100 ng/hr.