Content of sP-selectin and Cytokines in Blood of Patients with Type 2 Diabetes Mellitus and Arterial Hypertension Depending on Diabetes Compensation Condition

Abstract

<p>The goal of our research has been to study sР-selectin and cytokine content changes, namely ІL-2, ІL-6 and TNF-α in blood plasma of patients with type 2 diabetes mellitus with varying compensation for the disease and arterial hypertension, as well as to investigate a possible interrelation between sР-selectin and cytokines. To achieve the goal 137 patients with type 2 diabetes mellitus with AH of the І-ІІ stages and without AH (72 women and 65 men) have been examined. The levels of sР-selectin, ІL-2, ІL-6, TNF-a in blood serum were determined by means of immunoenzymatic assay method. As a result, a reliable increase in sP-selectin level in blood serum has been detected in patients with type 2 diabetes mellitus with deterioration of diabetes compensation along with АH; increase in ІL-6 level in groups with good and satisfactory compensation for diabetes and TNF -α in groups with bad compensation with the presence of АH.<em> </em>A reverse correlation between the content of sP-selectin and TNF-α in groups of those examined with non-compensated type 2 DM, associated with АH and without AH, stronger in a group of patients with type 2 DM and AH. The level of sP-selectin in blood increases with the deterioration of type 2 DM compensation along with AH. Most probable reverse correlations between sP-selectin and TNF-a levels in groups of patients with insufficient compensation for diabetes may indicate a mutually potential role of these factors in the development and progression of type 2 DM decompensation and AH.</p>