Abstract
The study investigated the dynamic changes in the content of pentraxin-3 and C-Reactive Protein in blood serum of children and adolescents suffering from respiratory tuberculosis with destruction and minor tuberculous changes in chest lymph nodes and lungs (minor forms). Level of PTX3 in tuberculosis patients with destructive lesions confidently reduced by the 6th month of treatment (end of the intensive phase of treatment): from 3 285.2 ± 387.1 down to 1 280.0 ± 65.4 pg/ml In the group ofthose with minor forms oftuberculosis the content of PTX3 confidently increased after 6 months of treatment (completion of the main course of chemotherapy): from 2 990.0 ± 330.3 down 5 329.7 ± 421.3 pg/ml. Such changes of PTX3 in this group were observed for the first time and it had not been described before. It is possible that the increase of PTX3 level after completion of chemotherapy course is temporary and it is related to activation of the lung tissue healing. Content of C-Reactive Protein before treatment start was typically higher in those with destructive lesions and it confidently reduced in 6 months of chemotherapy in the patients from this group (from 15.7 ± 2.9 down to 5.95 ± 1.2 mg/l) and remained unchanged in the patients with minor forms of tuberculosis (4.5 ± 1.1; 2.9 ± 0.1 mg/l).
Highlights
CONTENTOFPENTRAX IN -3 A N D C -REACT IV EPROTE IN IN BLOODSERUMOFCH IL DRENANDADOLESCENTSSUFFER IN GFROMRESP IR ATORYTUBERCULOS IS W IT HDESTRUCT IO NANDM IN ORFORMSOFTHED IS E A S E
Level of pentraxin 3 (PTX3) in tuberculosis patients w ith destructive lesions confidently reduced by the 6th m onth of treatm ent: from 3 285.2 ± 387.1 down to 1 280.0 ± 65.4 pg/m l In the group of those w ith minor forms of tuberculosis the content of PTX3 confidently increased after 6 months of treatm ent: from 2 990.0 ± 330.3 down 5 329.7 ± 421.3 pg/ml
Such changes of PTX3 in this group were observed for the first time and it had not been described before
Summary
Проведено когортное проспективное исследо вание, в которое включено 42 больных в возрасте от 3 до 17 лет с различными формами туберкулеза органов дыхания. Из 20 больных с деструктивными процесса ми 18 человек являлись бактериовыделителями (90,0%). Группу 2 составили 22 пациента (средний возраст 8,5 ± 0,9 года) с минимальными туберку лезными изменениями, определяемыми только с помощью компьютерной томографии (малые формы), со следующими клиническими формами: очаговый туберкулез легких (ОТ) - 9; туберкулез внутригрудных лимфатических узлов (ТВГЛУ) в фазе уплотнения и частичной кальцинации с оча гами отсева - 13 человек. Продукцию PTX3 изучали в плазме крови до на чала химиотерапии и через 3 и 6 мес. Для определения PTX3 использовали набор Duo Set Human Pntraxin3/TSG иммуноферментного анализа R@D (Великобритания). Содержание С-реактивного протеина определяли с помощью ИФА-набора (Вектор-Бест, Россия). Постановку реакции осуществляли согласно инструкции произ водителя. Результаты обрабатывали статистически с помощью Microsoft Exel
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