Abstract
The study was undertaken to examine the effect of oral administration of dimethoate (Bi 58 Nowy) and/or pyrantel tartrate on the concentration of glutathione (GSH) and vitamin C in rat liver. Rats of Group I were administered pyrantel tartrate at a dose of 85 mg/kg b.w. at a twoweek interval, while the animals of Group II received Bi 58 Nowy (38% dimethoate) at a dose of 25 mg/kg b.w. for 28 days, and animals of Group III received both compounds together as described above. Pyrantel tartrate was found to increase the concentration of glutathione in the liver, whereas the content of vitamin C oscillated around values reported for the control. After a 28-day exposure to dimethoate (Bi 58 Nowy), except for the 6th hour after intoxication, the content of GSH was observed to increase and significant differences (p ≤ 0.05) occurred after days 3 and 14 (p ≤ 0.01). The concentration of vitamin C in liver homogenates after dimethoate administration was decreased compared to the control until day 3. An increase was then observed continuing until the end of the experiment. In animals receiving both compounds, except for day 7, the concentration of vitamin C was slightly decreased. The administration of pyrantel tartrate before dimethoate (Bi 58 Nowy) only in some time intervals was found to reduce the intensity of changes evoked by the exclusive administration of insecticide. It may suggest that not in all cases of mixed intoxications, intensification should be expected in changes of the variables analyzed.
Highlights
The study was undertaken to examine the effect of oral administration of dimethoate (Bi 58 Nowy) and/or pyrantel tartrate on the concentration of glutathione (GSH) and vitamin C in rat liver
Administration of pyrantel tartrate to rats at the dose of 85 mg/kg b.w. (Group I) elevated the concentration of GSH compared to the control group, and the increase continued throughout the entire experimental period (Table 1)
An increase in the content of GSH was observed over the entire experimental period in the liver of rats intoxicated with pyrantel tartrate at the dose of 85 mg/kg b.w. administered twice in a two-week interval
Summary
The study was undertaken to examine the effect of oral administration of dimethoate (Bi 58 Nowy) and/or pyrantel tartrate on the concentration of glutathione (GSH) and vitamin C in rat liver. Dimethoate, pyrantel tartrate, glutathione, vitamin C, rat Amongst the threats posed by chemical substances, special attention should be paid to hazards linked to the use of pesticides (Jeyaratnam 1990; Steenland et al 1994, 1996). Due to their extensive use, the problem of their toxic interactions with various compounds, including drugs, becomes of key importance in terms of both biological and therapeutic effects observed as well as mechanisms affecting this phenomenon.
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